CreoFort

Creofort capsules contain a mixture of digestive enzymes, including lipase, protease, and amylase. Creofort capsules are a prescription medicine used to treat patients who cannot digest food normally because their pancreas does not produce enough enzymes for reasons such as cystic fibrosis, chronic inflammation of the pancreas (chronic pancreatitis), surgical removal of all or part of the pancreas (pancreatectomy), or other conditions. Creofort helps the body use fats, proteins, and sugars in food.

In adults and children over one year of age, the dosage of Creofort 2 capsules is 1 capsule with meals and 1 capsule with other snacks.

The initial dose for starting treatment and increasing the dose at each meal should be determined based on the clinical symptoms, the degree of fat in the stool, and the fat content of the individual’s diet.

Before taking Creno Forte capsules, tell your doctor about your medical conditions, including:

If you have a history of intestinal obstruction or ulceration with thickening of the intestinal wall (fibrosing colonopathy).

If you have gout, kidney disease, or high uric acid in the blood (hyperuricemia).

If you have difficulty swallowing capsules.

If you have any other medical conditions.

If you are pregnant or planning to become pregnant.

If you are breast-feeding or will soon breast-feed.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Warnings and Precautions

Taking very high doses of pancreatin may increase your risk of a rare intestinal disorder called fibrosing colonopathy. So if you experience any of the following symptoms that are unusual or severe, tell your doctor right away:

Abdominal pain

Bloating

Difficulty in defecation

Nausea, vomiting, or diarrhea

What is fibrosing colonopathy?

Fibrosing colonopathy is a rare but serious side effect that has been reported with very high, long-term doses of pancreatic enzymes, often in children with cystic fibrosis.

Patients with fibrosing colonopathy should be closely monitored by a doctor, as some patients may be at risk of developing intestinal strictures. In general, it is recommended that the daily dose of pancreatic enzymes should be less than 10,000 lipase units per kilogram of body weight unless higher doses are clinically necessary and in the opinion of a doctor. In this case, higher doses should be used with caution and only if, after 3 days of fecal fat testing, it is proven that the higher dose has significantly improved fat absorption.

However, the risk of this complication is reduced by strictly following the dosage prescribed by your doctor

Possible risk of increased blood uric acid
Patients with gout, kidney failure, or high blood uric acid should use Creofort capsules with caution, as this drug may increase blood uric acid levels.

Allergic reactions

Patients with a history of allergy to animal proteins should use Creofort with caution.

Severe allergic reactions have been reported rarely with other products containing pancreatic enzymes with different formulations. In patients with severe allergies, the risks and benefits of continuing treatment with pancreatic enzymes should be considered, taking into account the patient’s clinical needs.

Drug interactions

No drug interactions have been identified with the simultaneous use of other drugs with pancreatin.

Use in pregnancy and lactation
If you are pregnant or breast-feeding, think you may be pregnant or are planning to become pregnant, consult your doctor or pharmacist before taking this medicine.

Pregnancy Category: C
The effect of pancreatin on possible harm to the fetus of pregnant women or impairment of reproductive capacity in women has not been established. Therefore, pregnant women should take Creofort capsules only if clearly needed. The benefits and risks of taking pancreatin should be considered in consideration of the need for adequate nutritional support for a pregnant woman with pancreatic insufficiency, since adequate calorie intake during pregnancy is very important for normal maternal weight gain and fetal growth, and maternal weight loss and malnutrition can be associated with adverse effects during pregnancy.

Breast-feeding
It is not known whether pancreatin passes into human milk after use. However, Creofort capsules should be used with caution and under the advice of a physician in breastfeeding women.

Driving and using machines
There are no reports of the effect of Pancreatin on the ability to drive or use machines.

3- Creofort dosage and method of use:

Take Creofort capsules exactly as prescribed by your doctor, no more and no less. The daily dose of Creofort capsules should not exceed the maximum daily dose recommended by your doctor.

-Do not replace other products containing the enzyme Pancreatin with Creofort capsules without consulting your doctor.

-If you need to change the dose, this should be done gradually and over several days. Doses greater than 10,000 lipase units per kilogram of body weight per day should be taken with caution and according to your doctor’s advice.

-Always take Creofort capsules with a meal or immediately after a meal or snack and with enough liquid to help swallow the capsule completely.

-If you eat several meals or snacks throughout the day, be careful not to exceed the total maximum daily dose of Pancreatin capsules.

-Your doctor may change your dose based on your weight or the amount of fatty foods you eat.

-Take Creofort capsules with plenty of fluids and swallow them whole. Do not chew or crush the capsule and its contents or keep them in your mouth. Crushing, chewing or keeping the capsule and its contents in your mouth may cause irritation and sores in the oral mucosa or change the functional nature of the medicine.

-If you have difficulty swallowing the capsule, open the capsule slowly and pour its contents into a small amount of fruit juice or acidic food at room temperature, such as applesauce, and drink it immediately. Do not store the mixture.

-If you pour the contents of the capsule into acidic food, drink it immediately with plenty of water and make sure the medicine is swallowed whole.

-Do not mix the contents of the capsule with foods with higher acidity than